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Proc Natl Acad Sci USA 115(17):44834488

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Doctors are using a regulatory gap to prescribe an unauthorized peptide Experts urge authorities to close loophole Despite Health Canada's warnings against the use of unauthorized peptides as a health and fitness shortcut, a CBC News investigation uncovered doctors using a regulatory loophole to administer one of the unproven products to patients

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published in the Journal of Applied Physiology confirmed that BPC-157 significantly accelerated outgrowth of Achilles tendon explants, markedly increased in vitro tendon fibroblast migration in a dose-dependent manner, and substantially increased fibroblast survival under HO-induced oxidative stress establishing a three-part cellular mechanism (outgrowth, migration, survival) that distinguishes BPC-157s tendon repair profile from direct mitogenic agents