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Those who with neuropathy present with a warm, swollen, red foot requires a thorough work up for possible charcot neuroarthropathy, nonweight bearing and urgent referral to a foot care specialist to prevent foot deformities and instability leading to ulcerations and amputations

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DUB activity can be affected by the existence of such chains as is for example well illustrated by the finding that the DUB MINDY-1 only processes tetraUb or longer Lys48-linked chains 67