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Main reasons for changes in therapy are side-effects and insufficient therapy response, which highlight the importance of regular follow-up and screening for side-effects

However, the scarcity in recent clinical trials success has demonstrated that expanding the indications of existing small molecule anticancer agents for brain tumors and metastases can be challenging

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The study results showed improved dermal density, skin texture, and reduced wrinkles for all the treatment groups tested

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doi: 10.1097/BOR.0000000000000683 67 AndonianBJKossAKovesTRHauserERHubalMJPoberDMet al