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Structural basis for the regulation of human 5,10-methylenetetrahydrofolate reductase by phosphorylation and S-adenosylmethionine inhibition

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The docking scores of the most active compound 36 (IC50: 12.62 nM) and reference compound donepezil (IC 50 : 69.30 nM) against AChE were calculated as -7.291 and 6.492 kcal/mol, respectively

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These findings indicate that ORP5 can direct PA toward LD storage independently of seipin