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doi:10.4049/jimmunol.1102683

17 It is unclear whether this decreased dose of rasburicase (3 mg) mitigates hemolysis in patients with G6PD deficiency

The real magic happens at the cellular level

One small randomized controlled trial in 450 pregnant women in West Africa, without specified MTHFR genotype but at high risk for preeclampsia, found that supplementation with 15 mg of riboflavin daily was not effective in preventing the condition (29), but the study was likely underpowered to detect a significant effect

Molecular screening for gene variants may not appear practical or cost-effective traditionally because of the infrastructure and technical expertise required, but advancements are progressively making this more widely accessible in the form of gene chips