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Combined with peripheral dopa decarboxylase inhibitors in fixed-dose formulations, it is converted into dopamine after crossing the bloodbrain barrier, effectively compensating for the dopaminergic deficit in the nigrostriatal pathway and significantly improving core motor symptoms such as bradykinesia, rigidity, and tremor [100], long-term use is associated with motor complications including wearing-off phenomena, dyskinesias, and "onoff" fluctuations, as well as peripheral dopaminergic adverse effects such as nausea, vomiting, and hypotension [101, 102]

The good news is that AOD9604 is an FDA-approved drug as an anti-obesity drug, so you dont have to worry about adverse effects at all

Sade cardaca: estudos demonstram ao cardioprotetora em pacientes com angina e insuficincia cardaca

Stinchcombe TE, Socinski MA

This pain can be migratory, moving from one area of the body to another, and is often mistaken for fibromyalgia or arthritis

M et al