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In line with the latter, we detected an increase in protein levels of glutathione synthase (GSS), the enzyme responsible for addition of glycine to the -glutamyl-cysteine in GSH biosynthesis (Figs

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This shift is consistent with the SECs are in a state of cellular senescence or quiescence with an increased focus on maintaining existing protein function through post-translational modification (dephosphorylation) and tightly controlling gene expression (mRNA regulation), which is consistent with the characteristic dysfunction and loss of regenerative capacity seen in aged endothelium

Halim et al

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