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Mitochondrion 47 , 114124

To date, we have identified 25 genetically encoded selenoproteins in human, including glutathione peroxidase (GPx), thioredoxin reductase (TXNRD), and iodothyronine deiodinases (DIOs), which have a wide range of functions, from anti-inflammatory and antioxidant activities to thyroid hormone metabolism

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Gustafsson's research demonstrated that coronary plaques in symptomatic atherosclerosis patients exhibit higher iron concentrations and a greater risk of plaque rupture [178]

However, although the restoration of blood flow is essential during reperfusion, it is accompanied by a dramatic increase in oxidative stress and produce excessive ROS that damage cell membranes, mitochondria and DNA (23-25)

Lin Y-K, Liang C-H, Lin Y-H, Lin T-W, Vazquez JJ, van Campen A, et al