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Cohens d values were used to report the effect size, where 0.2 was considered a small effect size, 0.5 was a medium effect size, and 0.8 was a large effect size 80

In support of this view, we found that SIRT7-2E almost abolished the AMPK-mediated SKP2 phosphorylation at S256, while the effect on the SKP2-S256A mutant was less marked (Fig