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In summary, the brain microvascular endothelium differs from peripheral endothelium in three primary ways: 42 Transport Across the Blood-Brain Barrier The biochemical BBB is established by transport systems of the BBB, which can be grouped into four types (Fig

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2 Other crucial areas of uncertainty in clinical practice are related to the intensity and duration of DOAC therapy in patients with provoked VTE with enduring risk factors, 24 the efficacy and safety of DOACs for thromboprophylaxis in patients with mechanical valves, and the utility of DOACs for treatment of patients with left ventricular thrombus or heparin-induced thrombocytopenia