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Two key enzymes that control histone modifications are histone methyltransferases and deacetylases, and dysregulation of these enzymes may play a role in HT pathogenesis (Pu And Zhang 2024)

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To date, more than 600 distinct PTM types have been identified, including phosphorylation, acetylation, ubiquitination, sumoylation, methylation, glycosylation, palmitoylation and succinylation (Walsh et al., 2005)