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Request for additional data: PCAC may ask for more safety or efficacy information before making a final recommendation, potentially delaying the timeline

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NICE NG28 and the MHRA advise considering B12 monitoring in long-term metformin users who have symptoms or risk factors for deficiency, as metformin can impair B12 absorption in the terminal ileum

A druglike Ferrostatin-1 analogue as a ferroptosis inhibitor and photoluminescent indicator

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Application of TMA Formation Inhibitors In bacteria, there are several different enzyme systems involved in the conversion of TMA precursors to TMA that have been identified, including choline-TMA lyase (cutC/D), carnitine monooxygenase (cntA/B), yeaW/X TMA lyase, betaine reductase and TMAO reductase (Figure 3)