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However, these natural lines of defense in mitochondria can be altered after excessive consumption of or exposure to alcohol (ethanol) [85, 94], drugs [66, 102, 103], viruses [104], and some nutrients, including fructose [105]

M.CharpakS.LauritzenM.MacVicarB

These observations underscore the intrinsic selectivity in their proteinprotein interactions and suggest that the paralogs function non-redundantly in vivo