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High local potency Reported ~10-fold more potent than intact IGF-1 in cell culture because it escapes IGF-binding-protein sequestration

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The nuclear regulation of autophagy, especially the role of transcription factors and chromatin remodelers, has gained attention because of recent research advances

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494,495 Secondly, NMNAT and WldS proteins facilitate axon preservation by suppressing the accumulation of NMN

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Heme mediates derepression of Maf recognition element through direct binding to transcription repressor Bach1

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Using Primes suite of biochemical and targeted sequencing assays, initial studies detected no off-target editing in human hepatocytes

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