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Perhaps this applies especially to the third point

Also, there are differences in SASP expression profiles and functions between senescence-inducing conditions and cell types [54]

Meanwhile, LXR agonists and LDHA inhibitors have shown potential for coordinated regulation of lipid metabolism and glycolysis in animal experiments (23)

Through oral administration, it also can inhibit the IL-12 and TNF- expression, as other flavones can interact in the NF-B pathway in UC attenuated [110]

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Eicosatrienoic acid was below lower limit of normal throughout the trial and increased to a mean normal value by Week 104