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Based on plasma metabolomic and proteomic studies, multiple metabolic pathway aberrations have been detected in LC and ME/CFS samples, including changes in serotonin and tryptophan metabolism 14 , cholesterol metabolism 51 , dysfunctional gut microbial butyrate biosynthesis pathways 15,16 , oxygen transport to tissues 72 , and deficient mitochondrial fatty acid oxidation and ATP metabolism 17, 20

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Furthermore, lipid peroxidation and antioxidant enzymes in the blood have been identified as markers for vascular injury and microangiopathy in DM [314]

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Blue light exposure can induce diverse and complex histological and metabolic effects 5,8,10,13,14,15 , which vary depending on the specific tissue type and its manifestations, as briefly outlined above

Manski S, Noverati N, Policarpo T, Rubin E, Shivashankar R