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Overall, these data support the human observations and show increased zonulin levels, reduced TJ protein complex expression and impaired intestinal barrier function preceding the onset of arthritis

Niki E, et al

In addition, local treatment with DHA combined with pigment epithelium-derived factor (PEDF) can selectively recruit type 2 macrophages and prevent neutrophil infiltration from diabetic corneal injury, thereby promoting corneal nerve regeneration and wound healing in diabetic mice (131)