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Further research has shown that activated ErbB2 stimulates GLS expression in breast cancer cells through the PI3K/Akt-independent NF-B pathway (197)

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The net effect of combining these actions is not well characterised

154 m 6 A modifications promote mRNA destabilization of MXD2 transcript, thereby increasing c-Myc activity

Furthermore, men with detectable CTCs and elevated methylated markers in plasma had a poorer prognosis than those with either marker alone (Okegawa et al, 2010)