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Nowadays, some studies have suggested a potential co-regulation between HSPs and MTs in human diseases

In brown adipose tissue (BAT), prolonged cold exposure activates the -adrenergic signaling pathway, which triggers post-translational modifications activating PGC-1, thereby enhancing PGC-1 gene expression 76,77,78

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The disease is caused by pathogenic variants in the frataxin ( FXN ) gene that commonly consist of expanded GAA triplet repeats in its first intron resulting in transcriptional silencing and subsequent reduction in frataxin protein expression [1]

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