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Further confirmation for cell cycle exit in response to AIIB2 was seen during a time-course experiment on 2D BME-coated transwells loaded with a human ileal organoid line, stably expressing the fluorescent ubiquitination based cell cycle indicator (FUCCI) reporter(Extended Data Fig

A P -value of less than 0.05 denotes a statistically significant difference

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The delivery system includes those which by-pass gut and liver and thus first pass effect / metabolism

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In human melanoma cells, other mammalian cells, and in birds, depletion of GSH increases melanin deposition 23,24