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The inhibitory effect of system Xc-can induce ferroptosis in cisplatin-resistant HNSCC (143)

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While NHR-49 activity is required for normal aging as well as several longevity-promoting interventions 16 , hyperactivation of NHR-49 by limiting KIN-19 expression perpetuated a chronic state of lipid catabolism, abolishing the longevity benefits conferred by fasting