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Visible cosmetic results typically appear at 4-6 weeks and continue improving through 8-12 weeks of consistent use

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To better understand biofilm development and persistence in chronic wounds, Figure 2 illustrates the stages of the biofilm life cycle, including adhesion, microcolony formation, maturation, and dispersion, as well as host immune responses such as neutrophil recruitment, M1/M2 macrophage polarization, and cytokine signaling (e.g., interleukin-1 beta [IL-1], tumor necrosis factor-alpha [TNF-], interleukin-6 [IL-6], interleukin-8 [IL-8], interleukin-12 [IL-12]), which collectively contribute to immune evasion and chronic infection [40-43]

It appeared to lower the intensity of H2AX signals a marker of DNA damage and seemed to decrease apoptosis rates, as indicated by reduced Annexin-V staining

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