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Bcl-2 antisense oligodeoxynucleotide (Genasense) enhanced gemtuzumab ozogamicin (Mylotarg)-induced cytotoxicity in acute myeloid leukemia

doi: 10.1128/mSphere.00973-20 375 ShreazS.WaniW

Due to potential environmental sustainability concerns (collection of the hemolymph used in pharmaceutical testing may negatively affect horseshoe crab populations), a quantitative and more sensitive endotoxin assay was developed using a pyrogentesting cell model with knock-in of TLR4/CD14/MD2 at the safe harbor locus AAVS