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Description

Weir et al., 1972

Bile acids induce visceral hypersensitivity via mucosal mast cell-to-nociceptor signaling that involves the farnesoid X receptor/nerve growth factor/transient receptor potential vanilloid 1 axis

As such, it currently lacks standardized diagnostic criteria, validated biomarkers, and prospective clinical validation

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Similarly, symptoms may also appear more frequently during the clinical assessment than the patient reports as typical in their everyday life, owing to this heightened sense of attention, as well as the increased anxiety state associated with the clinical encounter (83)