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ATF4 transcription plays a key role in maintaining cellular homeostasis, thereby promoting cellular adaptation

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Glutathione deficiency contributes to oxidative stress leading to aging and the pathogenesis of many diseases (including kwashiorkor, seizure, Alzheimer's disease, Parkinson's disease, liver disease, cystic fibrosis, sickle cell anemia, HIV, AIDS, cancer, hea

GSTs are divided into 14 classes: phi (GSTF), tau (GSTU), theta (GSTT), zeta (GSTZ), lambda (GSTL), metaxin, hemerythrin (GSTH), iota (GSTI), glutathione-dependent dehydroascorbate reductase (DHAR), tetrachloro hydroquinone dehalogenase (TCHQD), -subunit classes of the eukaryotic translation elongation factor 1B (EF1B), glutathionyl hydroquinone reductase (GHR), GSTs with two thioredoxins (GST2N), and microsomal prostaglandin E synthase type 2 (mPGES2) 2,3

Front Pharmacol (2017) 8:296

Tops initiated partly the cell recovery following the cell mortality by tert -butyl hydroperoxide, which showed other relevant mechanisms rather than PI3K/Akt and HO-1 were responsible for Tops initiated cell recovery[]