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Interestingly, both citrate 63,64 and ASP 38 have gained a lot of attraction in recent years due to their rate-limiting effect on tumour cell proliferation, and inhibition of the ASP-ASN metabolic pathway in acute lymphoblastic leukaemia (ALL) is the first example of a tumour-metabolism-targeting therapy 65

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Ethical approval was obtained from the IRB committees at Faculty of Medicine, University of Helsinki, Helsinki, Finland, and at Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA

Battistin L, Pizzolato G, Dam M, and et al