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This inhibition appears to involve NADH/NADPH oxidase-mediated oxidative stress [5, 16, 80], a mechanism consistent with known Hcy-associated ROS generation [130]

Besides, it seems that individuals with manic episode showed the greatest reductions in tryptophan levels whereas KYNA levels were more notably reduced among individuals in the depressive phase [229]

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Biomarkers of immune activation such as NK cell activity, CD8 + T cell infiltration, cytokine profiles (IL-12, IFN- and IL10), and Treg/MDSC ratios help identify populations of patients likely to benefit from immunomodulatory agents whereas circulating levels of polyphenols, isoflavones or glucosinolate metabolites serve as a marker for PK properties that can be utilized to optimize dosing and exposure (224)