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One case of heterogeneity is due the up regulation in endothelial cells, associated with tumours, of the PI3K/AKT pathway which has been reported in some intra tumour endothelial cells [72] , one of the consequences is the variable response to angiogenic factors like VEGF and to their blockage [73]

Leyton-JaimesMFIvertPHoeberJHanYFeilerAZhouCet alEmpty mesoporous silica particles significantly delay disease progression and extend survival in a mouse model of ALS

Cardiovasc Res 47(1):81-9, 2000

These conditions typically include hypertension, cancer, and diabetes

J Endocrinol Investig 19:433440 Muoz MT, Barrios V, Pozo J, Argente J (1996) Insulin-like growth factor I, its binding proteins 1 and 3, and growth hormone-binding protein in children and adolescents with insulin-dependent diabetes mellitus: clinical implications

The compound of R 1 is C 1-4 -alkyl