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PMID: 37252795, PMCID: PMC10371339, DOI: 10.1172/jci.insight.160024

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These iron ions are taken up by cells through TF and its receptors, leading to intracellular iron accumulation, which catalyzes iron-dependent Fenton reactions, producing excessive ROS that cause lipid peroxidation and membrane damage (Meng et al., 2017