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Within 20 minutes, DA-AZI NPs were broadly distributed throughout the biofilm, and by 40 minutes, they had penetrated nearly the entire structure ( Figure 3D )

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Figure 1 (B) NETs induce glioma cells to secrete IL-8 to recruit neutrophils, promote the CXCR2/PI3K/AKT/ROS signalling axis, and finally promote the formation of NETs, forming a positive feedback pathway ( (C) Cytokines and growth factors, such as granulocyte-macrophage colony stimulating factor (GM-CSF), granulocyte colony stimulating factor (G-CSF), IL-2, IL-1, IL-6, and VEGF, can induce the aggregation of MDSCs in tumour hosts (102, 103)

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