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Unlike full-length hGH, AOD9604 does not bind the growth hormone receptor and does not elevate IGF-1 or interfere with glucose homeostasis in published research models a distinction that has made it a valuable comparator compound in metabolic studies

45 In vivo administration of GSH has been demonstrated to enhance the activation of cytotoxic T-cells, but depletion of GSH intracellularly inhibited the activation of lymphocytes, increased susceptibilities of human lymphoid cells to radiation, and suppressed cell-mediated cytotoxic functions, suggesting that intracellular GSH can modulate the function of immune cells

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EMBO Rep 18:894905 Stankovic A, Guo LY, Mata JF, Bodor DL, Cao XJ, Bailey AO, Shabanowitz J, Hunt DF, Garcia BA, Black BE et al (2017) A dual inhibitory mechanism sufficient to maintain cell-cycle-restricted CENP-A assembly