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The experimental group received the standard NP therapy along with 120 mg Artesunate once daily via intravenous injection from the 1st to the 8th day, for 8 days

Compositional imbalances in microbial communities can alter their metabolic profiles, thereby disrupting host immune homeostasis, compromising defense mechanisms, and potentially triggering local and systemic inflammation [9]

After tramadol exposure, the expression of BDNF decreased, and the expression of apoptosis and autophagy genes increased in the striatum and hippocampus 66