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Acknowledgements This study is supported, in part, by the University of Kansas Medical Center Endowment Fund, and by research grants from Shenzhen Key Laboratory of Steroid Drug Discovery and Development (grant # ZDSYS20190902093417963) and the National Natural Science Foundation of China (grant # 81630096)

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[9] Parenteral diphenhydramine is contraindicated in premature or full-term neonates because of heightened anticholinergic central toxicity and paradoxical excitation