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To harness the protein-degradation activity of this HSP90 chaperone complex, we developed a novel targeted protein degradation technology, termed Chaperone-Mediated Protein Degradation (CHAMP), and an ERK5-CHAMP was designed to induce chemical proximity between HSP90 and ERK5 to induce ERK5 degradation

Conversely, lipids associated with anti-inflammatory effects, such as DHA and eicosatetraenoic acid, also increased by ~42% and ~53%, respectively, suggesting a compensatory or adaptive lipidomic remodeling response

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Paumgartner, G., & Beuers, U

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Ultimately, the optimal reaction conditions employed 10 mol% PhSeBr ( C5 ) in 1,4-dioxane at room temperature in air