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The pharmacological rationale rests on the concentration-dependent bactericidal activity of aminoglycosides, whereby higher peak-to-MIC ratios enhance killing efficacy, combined with the saturable nature of aminoglycoside uptake into renal tubular and cochlear hair cells: prolonged drug-free intervals between doses may reduce cumulative intracellular drug loading and thereby the potential for organ toxicity ( Meta-analytic evidence consistently supports extended-interval dosing as at least equivalent to multiple daily dosing in efficacy and safety

2025;16:1582587.[DOI] 79

doi:10.1007/s40265-022-01717-z 7

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Services on Demand Journal Article Indicators Cited by SciELO Access statistics Related links Similars in SciELO Share Revista Colombiana de Obstetricia y Ginecologa Print version ISSN 0034-7434 On-line version ISSN 2463-0225 Rev Colomb Obstet Ginecol vol.53 no.4 Bogot Oct./Dec

CD4 + T cells, especially Th1 subsets, play a central role by secreting interferon-gamma (IFN-) to activate macrophages, while CD8 + T cells contribute through cytotoxic activity and cytokine production (Liu et al., 2025)