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Melatonin and its metabolites are transported to cells via the cell oligopeptide transporter (PEPT) 1/2 , the organic anion transporter (OAT) 3 and the glucose transporter ( via PEPT1/2 may be involved with its oncostatic effects ( The first report on the potent action of melatonin as a scavenger of direct free radicals occurred 30 years ago ( Melatonin has recently been reclassified as a multitasking molecule, and not exclusively a hormone, due to the finding about the existence of essential enzymes for its synthesis and the presence of melatonin receptors in many tissues and, also, the discovery of its antioxidant and generalized anti-inflammatory properties ( Melatonin functions as a glycolytic molecule which inhibits pathological aerobic glycolysis of diseased cells allowing them to resume normal mitochondrial oxidative phosphorylation

In animal models, inoculation of pre-formed -synuclein fibrils or pathogenic -synuclein species induces time-dependent appearance of phosphorylated -synuclein pathology in the dorsal motor nucleus of the vagus and downstream brain regions

Coradini, D

Xiao D, Bird IM, Magness RR, Longo LD, Zhang L: Upregulation of eNOS in pregnant ovine uterine arteries by chronic hypoxia

Croatica 72, 145156