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After nebulization, the nanoreactors exhibited superior pulmonary accumulation in orthotopic lung cancer-bearing mice, with 70-fold higher than intravenously injected nanoreactors at 12 h post-administration, and distributed deeply in the tumors

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This model dependence raises concerns about the translatability of findings, as mechanisms identified in acute models may not apply to chronic, clinically relevant RF

Increased eNAMPT levels were additionally reported in non-metabolic chronic inflammatory diseases [i.e., osteoarthritis (103) and acute lung injury (ALI) (165, 166)], characterized by systemic inflammation

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Inhibicin de la descomposicin: Ayuda a regular las metaloproteinasas de la matriz (MMP), las enzimas que degradan el colgeno y la elastina