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A phase I, doubleblind, placebo-controlled study of the tolerance and pharmacokinetic behaviour of RP 59500

In cases of overdose, high levels of acetaminophen can cause hepatocellular necrosis and liver damage from alteration of the cellular redox potential and damage from the NAPQI toxin, especially if the GSH levels are decreased in starvation

It is injected under the skin every two to four weeks and has a low risk of side effects, although rarely it may precipitate a life-threatening allergic reaction

In addition, cancer cells display increased expression of phosphoribosyl amidotransferase (PPAT), the enzyme that transfers amide nitrogen from glutamine to 5phosphoribosyl pyrophosphate (PRPP), a key reaction in purine biosynthesis (Goswami et al , 2015)

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Milazzo JP, Vaudreuil L, Cauliez B, Gruel E, Mass L, Mousset-Simon N, Mac B, Rives N