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doi: 10.3389/fcvm.2022.864600 Received 28 January 2022 Accepted 16 May 2022 Published 13 June 2022 Volume 9 - 2022 Edited by Emiel Van Der Vorst, Institute for Molecular Cardiovascular Research (IMCAR), Germany Reviewed by Christoph Reinhardt, Johannes Gutenberg University Mainz, Germany

other potential treatments other potential treatments naloxone The efficacy of naloxone in reversing CNS depression in this situation is debatable

Atrazines ability to cross the blood-testis barrier and obstruct the connection between Sertoli cells and germ cells provides an additional rationale for its negative histopathological effects

(I've described my distaste for the entire concept of antidotes in a previous column, arguing that the term leads to muddy thinking and failure to weigh critically whether or not a specific intervention is indicated in individual cases.) Dr Juurlink is careful to point out that the vast majority of VPA overdose cases will not need a carbapenem because most patients improve with routine treatment