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stimulated macrophage cell activation, leading to the upregulating of pro-inflammatory cytokines, including TNF-, IL-6, and IL-10

The brain has a high level of metabolic activity and therefore cerebral tissues require an immediate and constant supply of oxygen

191 SonnenbichlerJ.ZetlI

Its intrinsic properties, including high cell permeability, the ability to easily cross both the bloodbrain and placenta barriers, and its role as an endogenous reservoir of free radical scavengers (with indirect extra activities), confer it beneficial uses as an adjuvant in the biomedical field

One animal study examining the effects of aloe vera on gastric acid secretion and gastric mucosal health found that aloe vera balanced acid secretion and, at low doses, protected mucosa from temporary influxes of excess gastric acid

In addition to succination, whose signalling is beyond the scope of this review and has been reviewed before [56], in the next sections, we will discuss the different signalling cascades triggered by FH loss and fumarate accumulation