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To address this clinical need, we developed an assay to screen molecular libraries to identify novel hits that can inhibit the specific binding between Munc13-4 and STX7, two modulators of endolysosomal function necessary for eTLR activation

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The limited OHC loss indicates that mechanisms other than direct hair cell death, such as synaptic degeneration, ANF loss, and mitochondrial dysfunction, play a role in hearing impairment [9, 44]