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B12 injections can help improve mood and reduce symptoms of depression

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[7] High-dose methionine may antagonize the therapeutic effect of L-dopa-carbidopa regimens by increasing peripheral methylation of the drug complex, potentially reducing central bioavailability

IV infusions achieve near-complete bioavailability by delivering B12 immediately into the vasculature

Some researchers have also proposed that cleared FTPP might compete with creatinine for transport systems in the proximal tubule, which would explain the creatinine elevation without true glomerular damage