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However, our data suggest several potential paths forward: both Osimertinib and CP-24 sensitize GBM cells to temozolomide and radiotherapy, downregulate DNA repair pathways, and reduce PD-1 protein levels, raising the prospect of rational combinations with standard-of-care treatments and/or immune checkpoint blockade

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Owen & D.A

Chronic IH may also result in an imbalance in the ratio of arginase-1 (an enzyme that competes with eNOS for L-arginine) to eNOS expression, resulting in decreased NO availability, a key feature of ECD [149]