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A more reliable technique is to reduce (knockdown) expression of the gene product, which can be achieved with RNA interference therapies that use a cells own machinery for regulating protein expression or with antisense oligonucleotides (ASO)

Zhang H, Yue X, Chen Z, Liu C, Wu W, Zhang N, et al

doi: 10.1007/s40263-015-0272-9 Summary Keywords polycystic ovary syndrome, nutrients, vitamins, minerals, bioactive compounds, metabolism Citation Zhang Y, Shi B, Tian Y, Xu S and Chang H (2026) Nutrients and bioactive compounds in polycystic ovary syndrome: updated insights into effects and underlying mechanisms