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Retinoic acids and hepatic stellate cells in liver disease

The classic processing method for Hirudo (Shuizhi) is stirfrying with heated talcum powder: the segments of Hirudo (Shuizhi) are stirfried together with heated talcum powder until they slightly swell and turn yellowishbrown, which denatures and inactivates toxic proteins such as hirudin, significantly reducing their anticoagulant activity and thereby achieving detoxification [105]

Data from an anti-PD-1 immunotherapy cohort of 17 HCC patients (Fudan Cohort) were obtained from a published study 15

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doi: 10.3390/cancers10120481, 80