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Description

McDonnell, D

Furthermore, while biological agents targeting specific inflammatory pathways have demonstrated promising clinical outcomes, approximately 3050% of patients either fail to respond initially or develop neutralizing antibodies that diminish therapeutic effectiveness over time

Greenfield, R

Buch SC, Nazar-Stewart V, Weissfeld JL, Romkes M

[PubMed: 23982356] (Discussion of FDA warning that acetaminophen may cause Stevens Johnson Syndrome [SJS] or toxic epidermal necrolysis [TEM], a review identifying at least 91 cases, some with no other exposures and others with a positive rechallenge)