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Gelam honey markedly inhibited these pathways in HIT-T15 pancreatic islet cells at concentrations as low as 20 g/mL ( In vivo , oral administration of Malasyian gelam honey (12 g/kg) reduced leukocyte infiltration and edema in carrageenan-induced rats, thus attenuating acute inflammatory responses ( Tualang honey, collected by Apis dorsata bees from Malaysian rainforests, is especially abundant in phenolic acids and flavonoids

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Another study showed that calmangafodipir protected against small fiber neuropathy in an oxaliplatin-induced BALB/c mouse model, and interestingly, in addition to consistent with previous findings, calmangafodipir showed a U-shaped effect, with the 10 mg/kg dose less effective than the 2.5 and 10 mg/kg doses [156]