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Separately, a hip-fracture recovery trial in patients over 80 was terminated early after 6.5% of MK-677 recipients developed congestive heart failure versus 1.7% on placebo, alongside elevated blood pressure and glucose

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In the STEP 1 trial, once-weekly semaglutide 2.4 mg plus lifestyle intervention produced about 14.9% mean weight loss at 68 weeks, compared with about 2.4% with placebo