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In this review, we synthesize clinical and preclinical evidence demonstrating that KP dysregulation constitutes a convergent mechanism linking stress, inflammation, excitotoxicity, and oxidative stress in MDD, and critically evaluate its potential as a source of biomarkers and therapeutic targets (see Fig

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Leveraging the microbiome to understand clinical heterogeneity in depression: findings from the T-RAD study

The circulating levels of CD4+ t helper cells are higher in bipolar disorder as compared to major depressive disorder