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Sirima SB, Gansane A (2007) Artesunate-amodiaquine for the treatment of uncomplicated malaria

Patients reported feeling much more energized after a 3-month schedule of B12 injections

When plasma proteins are lower than normal, total drug concentrations will be lower but unbound concentrations will not be affected

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Current research extrapolations suggest 1216 week treatment cycles followed by 48 week rest periods, though this is based on precautionary principle rather than evidence of receptor desensitization or tolerance development

Because it is a stimulant medication, it can also cause insomnia 2